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Why ExpressTec

ExpressTec Proteins: Pure, Safe, and Accessible

ExpressTec changes the paradigm of recombinant-protein manufacture. Traditional production-scale processes rely on bacterial, yeast, or mammalian cell-culture expression systems, transgenic animals, or purification from natural sources. The limitations of these approaches include inadequate or non-sustainable supply from naturally occurring sources; low manufacturing yields with high capital-investment requirements and operating costs, and associated high cost of production; and potential for contamination from by-products present in the background organism or natural source.

Using ExpressTec, our scientists have been able to harness the natural life cycle and growth of rice as a background in which to manufacture highly pure recombinant proteins.

ExpressTec offers:

  • High product yields:┬áten-fold higher yields compared to other plant expression systems.
  • Safe background: orally available products produced in a plant that is safe for oral delivery.
  • Eukaryotic expression system: rice can manufacture complex biologics that are difficult to make in other hosts, including proteins requiring post-translational modification.
  • Flexibility: ability to manufacture multi-subunit molecules, monoclonal antibodies, fusion proteins, and enzymes.
  • Purity: products that are inherently free of animal, human, or microbial by-products, making them ideal for therapeutic use or for use in sensitive and exacting biotechnology applications.
  • Cost-effectiveness: suitable for cGMP manufacturing with dramatically lower cost of production.
  • Scalability: recombinant protein yields from kilograms to hundreds of metric tons.
  • Simplicity: batch-purification uses a simple, scalable, aqueous process with a 12 to 16-hour batch time.
  • Storability: mature ExpressTec grain can be stored without product degradation.
  • Biosecurity: ExpressTec plants are self-pollinating, maintaining genetic purity, with a chain of custody trackable from target gene to final biologic.
  • Environmental responsibility: the manufacturing process comes with a reduced carbon footprint.

InVitria Case Study

InVitria is an innovative biotechnology company that serves customers in the fields of industrial cell culture and biomanufacturing. Leveraging the capabilities and benefits of ExpressTec, InVitria has developed a product family of serum-free, animal-free cell-culture supplements, components, and custom media services to improve the performance of eukaryotic cell culture for both research and industrial applications.

Read Case Study