Our Science

Simply the Best

Selected Publications

Chen YS, Zaro JL, Zhang D, Huang N, Simon A, Shen WC. Characterization and Oral Delivery of Proinsulin-Transferrin Fusion Protein Expressed Using ExpressTec. Int J Mol Sci. 2018;19(2)

MacManus CF, Collins CB, Nguyen TT, Alfano RW, Jedlicka P, de Zoeten EF. VEN-120, a Recombinant Human Lactoferrin, Promotes a Regulatory T Cell [Treg] Phenotype and Drives Resolution of Inflammation in Distinct Murine Models of Inflammatory Bowel Disease. J Crohns Colitis. 2017;11(9):1101-1112.

Alfano R, Youngblood BA, Zhang D, Huang N, MacDonald CC. Human leukemia inhibitory factor produced by the ExpressTec method from rice (Oryza sativa L.) is active in human neural stem cells and mouse induced pluripotent stem cells. Bioengineered. 2014;5(3):180-185.

Broz A, Huang N, Unruh G. Plant-based protein biomanufacturingGen Eng Biotechn News. 2013; 33(4).

Zhang D, Lee HF, Pettit S, Zaro JL, Huang N, Shen WC. Characterization of transferrin receptor-mediated endocytosis and cellular iron delivery of recombinant human serum transferrin from rice (Oryza sativa L.). BMC Biotechnology. 2012;12:92.

Steere AN, Bobst CE, Zhang D, Pettit S, Kaltashov IA, Huang N, Mason AB. Biochemical and structural characterization of recombinant human serum transferrin from rice (Oryza sativa L.). J Inorg Biochem. 2012;116:37-44.

Laffan AM, McKenzie R, Forti J, Conklin D, Marcinko R, Shrestha R, Bellantoni M, Greenough WB. Lactoferrin for the prevention of post-antibiotic diarrhoeaJ Health Popul Nutr. 2011;29 (6):547-551.

Zhang D, Nandi S, Bryan P, Pettit S, Nguyen D, Santos MA, Huang N. Expression, purification, and characterization of recombinant human transferrin from rice (Oryza sativa L.)Protein Expr Purif. 2010;74 (1):69-79.

Tang L, Cui T, Wu JJ, Liu-Mares W, Huang N, Li J. A rice-derived recombinant human lactoferrin stimulates fibroblast proliferation, migration, and sustains cell survivalWound Repair Regen. 2010;18 (1):123-131.

Cerven D, DeGeorge G, Bethell D. 28-Day repeated dose oral toxicity of recombinant human apo-lactoferrin or recombinant human lysozyme in rats. Regul Toxicol Pharmacol. 2008;51 (2):162-167.

Cerven D, DeGeorge G, Bethell D. 28-day repeated dose oral toxicity of recombinant human holo-lactoferrin in rats. Regul Toxicol Pharmacol. 2008;52(2):174-179.

Moneret-Vautrin DA, Astier CMN, Franck P, Morisset M, Codreanu F, Roitel O, Taylor SL, Bethell DR. Assessment of the potential cross-allergenicity between hen’s egg lysozyme and recombinant human lysozyme. J Allergy Clin Immunol. 2007;119 (1):S109.

Zavaleta N, Figueroa D, Rivera J, Sanchez J, Alfaro S, Lonnerdal B. Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea. J Pediatr Gastroenterol Nutr. 2007;44 (2):258-264.

Lönnerdal B. Recombinant human milk proteins. In: Rigo J, Ziegler EE, eds. Protein and Energy Requirements in Infancy and ChildhoodKarger Publishers; 2006:207-217.

Bethell DR, Huang J. Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrheaBiometals. 2004;17 (3):337-342.